Obesity Linked to Fat Gain in Muscles
on 10/14/2005


FRIDAY, Oct. 14 (HealthDay News) -- The skeletal muscle of severely obese people is specially programmed to amass fat, researchers report.

The finding suggests the muscle has a metabolic "memory" of obesity, and it may explain why obese people have such a hard time losing weight, even when they cut calories.

The study in the October issue of Cell Metabolism also suggests that exercise may be able to override this programming and improve the ability of the obese to shed unwanted pounds.

Researchers found that the fat-building enzyme stearoyl-CoA desaturase-1 (SCD-1) is three times more abundant in the muscle of obese people than the muscle of lean people. This finding provides insight into an important link between obesity, diabetes and abnormal fat buildup in muscle, the researchers said.


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